{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##
<< Return to UMaryland Home
University of Maryland School of Medicine
  • Sign In
  • Live Courses
  • Online Courses
  • Learning from Teaching
  • CME Planning and Resources
  • About
  • Contact Us
  • Help
Close Login
{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##

If you have a UMID, click the "Sign in with your UMID" button below.

If you do not have a UMID, but created an account in the past, click the "Sign in with your email and password" button below.

If you do not have a UMID and have not created an account in the CloudCME system, click the "Create an Account" button below.

Create an Account

Sign in with your UMID
Sign in with your email and password
Enter your email and password to login:

*
*
Login

New to CloudCME? Create an Account:

Create New Account
Back to Login Provider Forgot Your Password?

Forgot Your Password?







Back to Login
{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##
Email is required Invalid: Enter valid email address
First Name is required
Last Name is required
Password is required


Password Requirements

  • Must be between 8 and 16 characters in length
  • Must Contain at least 1 upper case character
  • Must Contain at least 1 lower case character
  • Must contain at least 1 numeric character
  • Must contain at least 1 of the following ! * @ # $ % ^ & + =
Confirm password

Passwords must match
Password must be between 8 and 16 characters and contain the following:
•at least 1 upper case character
•at least 1 lower case character
•at least 1 numerical character
•at least 1 special character

  • -- Select Degree --
  • APRN
  • BS
  • BSN
  • CMA
  • CNA
  • CNM
  • CRNP
  • DDS/DMD
  • DO
  • DPM
  • JD, PhD
  • LCSW
  • LCSW-C
  • LPN
  • MBA
  • MBBS
  • MBChB
  • MD
  • MD, PhD
  • MPH
  • MS
  • MSN
  • MSW
  • None
  • NP
  • OD
  • Other
  • PA
  • PhD
  • RN
Degree is required
Please enter your degree:
You must enter a degree

Profession is required




Back to Login
Close Search Site Search: Enter your search terms in the field below to view results.

please enter a term to search
Close Specialties
{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##

Clozapine Bootcamp: Why, When and How to Use this Evidence Based Treatment

  • Overview
  • Register
  • Launch Course


Date & Location
Wednesday, January 1, 2025, 7:00 AM - Wednesday, December 31, 2025, 1:00 PM

Overview

 

This course is designed to equip healthcare professionals with the knowledge and skills necessary to navigate the complexities of clozapine management. Participants will delve into the challenging logistics of clozapine use, including the intricacies of the clozapine REMS (Risk Evaluation and Mitigation Strategy) program, and the management challenges associated with transitions of care, contraindications, and barriers to use.
The course will provide a comprehensive understanding of clozapine pharmacology, efficacy, and indications for use. Participants will learn effective communication strategies for discussing clozapine treatment with patients and their families, as well as gain insights into treatment guidelines, dosing, titration, and augmentation strategies.


In addition, the course will build confidence and competence in identifying, mitigating, and treating adverse events, with a focus on both common and rare side effects. Through case studies and discussions, participants will refine their proficiency in all aspects of clozapine care, enabling them to apply their knowledge and experience to improve patient outcomes.


This course is essential for healthcare providers seeking to deepen their expertise in clozapine management and enhance their clinical practice in the treatment of patients requiring this complex medication.


Disclosure: It is the policy of the University of Maryland School of Medicine to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities.  In accordance with this policy, all persons in a position to control the educational content of this educational activity must disclose any relevant financial relationships they have with ineligible companies. None of the planners/speakers for this educational activity have relevant financial relationships to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients.

Discussion of Off-Label or Investigational Uses 
Presentations in this continuing medical education activity may contain references to unlabeled or unapproved uses of drugs or devices.  The audience is advised to consult the full prescribing information of all drugs or devices prior to use. Some drugs/devices identified during this activity may have United States Food and Drug Administration (FDA) clearance for specific purposes only or for use in restricted research settings.  The FDA has stated that it is the responsibility of the prescribing health care professional to determine the FDA status of each drug or device that he/she wishes to use in clinical practice, and to use the products in compliance with applicable law.

UMSOM requires that all contributors disclose any unlabeled use or investigational use (not yet approved for any purpose) of pharmaceutical and medical device products and provide adequate scientific and clinical justification for such use.  Physicians and other healthcare professionals are urged to fully review all the available data on products or procedures before using them to treat patients.
Disclaimer

This CME activity is designed for use by healthcare professionals for educational purposes only.  Information and opinions offered by the contributors represent their viewpoints. Conclusions drawn by the participant should be derived from careful consideration of all available scientific information. Prescription information and use of medical devices should be undertaken only after confirmation of information by consulting the FDA-approved uses and information. 

While UMSOM makes every effort to have accurate information presented, no warranty, express or implied, is offered with respect to the information presented. Each participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information provided in this CME activity.

 


Accreditation

The University of Maryland School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Maryland School of Medicine designates this Live activity for a maximum of 17.25 AMA PRA Category 1 Credits TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Credits
AMA PRA Category 1 Credits™ (17.25 hours), Non-Physician Attendance (17.25 hours)

Mitigation of Relevant Financial Relationships


University of Maryland School of Medicine adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

No faculty are available for this activity at this time.

Efficacy and Effectiveness of Clozapine in Schizophorenia Related Disorders, Risk to Benefit Consideration and Off Lable Use

Deanna L. Kelly, PharmD., BCPP


Learning Objectives 

  • Describe the efficacy and effectiveness of clozapine in psychotic disorders 
  • Compare the efficacy and effectiveness of clozapine with other antipsychotic medications 
  • Analyze the risk t benefit considerations of clozapine use
  • List some off-label uses of clozapine

 

 

Launch Video
Pharmacology, Mechanism of Action of Clozapine, and Treatment Guidelines

Deanna L. Kelly, PharmD. BCPP

 

Learning Objectives

  • Describe the proposed mechanism(s) for clozapine
  • Discuss the pharmacological profile of clozapine
  • Use the treatment guidelines for schizophrenia to assess when to use clozapine

 

Launch Video
How to Determine if Someone has Treatment-Resistant Schizophrenia

Robert W. Buchanan, MD

 

Learning Objectives 

  • List the criteria by which a patient is determined to have treatment-resistant schizophrenia
  • Describe other reasons that may impact optimal treatment response
  • Differentiate between treatment resistant symptoms and inadequate medication trials

 

Launch Video
Barriers to Clozapine Use and Tips for Implementation of Clozapine Use in Team-Based Settings

Deanna L. Kelly PharmD., BCPP and Gopal Vyas, DO

Learning Objectives 

  • List the most common barriers to clozapine use
  • Examine barriers that can be best overcome to improve clozapine use 
  • Describe how using a team-based approached can facilitate clozapine use


 

Launch Video
Contraindications to Clozapine and Pre-clozapine Workup/Initiation Guidance

Gopal Vyas, DO

Learning Objectives

  • List the absolute contraindications to clozapine use
  • Differentiate between absolute and relative contraindications to clozapine use
  • Describe the components of a pre-clozapine workup
Launch Video
Dosing and Titration of Clozapine

Gopal Vyas, DO

Learning Objectives 

  • Describe the recommended and targeted dosing for clozapine
  • Evaluate titration strategies and the effects of titration on side effects and tolerability
  • Examine best strategies for cross tapering other medications when starting clozapine

 

 

 

 

 

 

 

 

 

 

 

 

Launch Video
Clozapine and Hematologic Montioring Fcus on Neutropenia and Use of Point of Care Monitoring Device

Deanna L. Kelly, PharmD., BCPP and Gopal Vyas D.O. 

Learning Objectives

  • List Types of hematologic side effects that can occur with clozapine 
  • Describe the FDA recommended criteria for absolute neutrophil count (ANC) monitoring for clozapine in the US
  • Compare and contrast point of care monitoring and venous blook draws for clozapine

 

Launch Video
Clozapine and Severe Neutropenia: Presentation, Treatment, Mechanism and Rechallenge

Gopal, Vyas, D.O.

Learning Objectives 

  • Defining the criteria for severe neutropenia 
  • Describe the potential mechanism by which severe neutropenia develop. 
  • List the treatment options for severe neutropenia
  • Discuss the potential for rechallenge after severe neutropenia
Launch Video
How and When to Use Clozapine Blood Levels

Gopal Vyas, D.O.

Learning Objectives 

  • Apply knowledge of clozapine metabolism and metabolic ratios to make decisions regarding adherence or unusual drug metabolism
  • Review clozapine metabolism and kinetics to make decisions regarding the introduction or withdrawal of strong inhibitors and inducers 
  • Apply knowledge of clozapine metabolism and kinetics to safely adjust dose when a serious infection is present

 

Launch Video
Clozapine and Constipation: Montioring, Prevention, Acute Treatment and Paitient Communication

Gopal Vyas, D.O.

Learning Objectives 

  • Describe recommendations to prevent constipation in clozapine-treated patients 
  • List the monitoring parameters for constipation
  • Outline the acute treatment options for constipation n clozapine-treated patients
  • Express how to communicate with patients about constipation



Launch Video
Tachycardia, orthostatic hypotension, syncope and sedation with clozapine

Megan Ehret, PharmD, MS, BCPP

Learning Objectives 

  • Recognize common adverse effects with clozapine and their associated prevalence
  • Assess the relationship dosing to sedation, orthostasis and tachycardia
  • Discern treatment strategies to manage these adverse drug reactions

 

Launch Video
Clozapine and Myocarditis, Cardiomyopathy and Fever: Potential Mechanisms, Risk Mitiagation and Rechallenge of These Side Effects

Fred Nucifora, Ph.D., D.O., M.H.S.

Learning Objectives 

  • Describe the prevalence of cardiac-related adverse events with clozapine
  • List risk factors and symptoms of myocarditis and cardiomyopathy during clozapine treatment 
  • Outline monitoring parameters for myocarditis and cardiomyopathy in clozapine-treated patients and strategies for prevention
  • Discuss the potential for rechallenge in patients who have recovered from clozapine-associated myocarditis or cardiomyopathy

 

Launch Video
Clozapine and Seizures; Reducing Risk, Monitoring and Managment

Gopal Vyas, DO

Learning Objectives 

  • Review the seizure risk and black box warnings associated with clozapine
  • Describe the risk and benefits and the role of dose in seizure and prevention
  • Identify evidence-based seizure management strategies and the role of prophylactic treatment

 

Launch Video
Weight and Metabolic Management of Clozapine

Megan Ehret, PharmD, MS, BCPP

Learning Objectives 

  • Describe the risk of weight gain an metabolic changes with clozapine
  • Discuss monitoring parameters for weight gain and metabolic parameter during clozapine treatment
  • List nonpharmacological and pharmacological interventions for prevention of weight gain
  • Assess treatment strategies for weight loss in overweight/obese patients
Launch Video
Clozapine Use in Patients with Suicidality, Aggression, Violence and Impusivity

Gopal Vyas, D.O.

Learning Objectives 

  • Review recent data on suicide incidence
  • Examine InterSePT Study results
  • Review data on violence and schizophrenia
  • Examine literature on clozapine and violence reduction
Launch Video
Other Clozapine Side Effects; Interstitioal Nephritis, Hepatic Abormalities, Tardive Dyskinesia, Neuroleptic Malignant Syndrome

Ikwunga Wonodi, M.D. M.B.A and Fred Nucifora, D.O., M.H.S., Ph.D.

Learning Objectives 

  • Describe the potential risk of interstitial nephritis in clozapine-treated patients
  • Review the hepatic abnormalities associated with clozapine treatment
  • Analyze the potential for tardive dyskinesia in clozapine-treated patients and compare/contrast with other antipsychotics
  • Discuss the presentation of Neuroleptic Malignant Syndrome in clozapine-treated patients, and compare/contract with other antipsychotics
Launch Video
Clozapine and African American Patients: Underuse, Benign Ethnic Neutropenia (BEN), Safety Considerations and Characterization

Ikwunga Wonodi, M.D. and Fred Nucifora, Ph.D., D.O., M.H.S

Learning Objectives 

  • Discuss the underuse of clozapine in African American patients and rationale for underuse
  • Characterize Benign Ethnic Neutropenia and understand new FDA guidelines for Absolute Neutrophil Count (ANC) monitoring in this population 
  • Recognize the safety of using clozapine in this population and expectations for ANC values during treatment
Launch Video
Overview and Management of Sialorrhea with Clozapine

Fred Nucifora, Ph.D., D.O., M.H.S

  • Describe the prevalence of sialorrhea with clozapine
  • Discuss the risks of sialorrhea in clozapine-treated patients
  • List the pharmacological and nonpharmacological intervention options for clozapine-induced sialorrhea
Launch Video
Clozapine and Tratment in Young Patients and Peer Support for Patients and Families

Gloria Reeves, MD and Heidi Wehring, PharmD

  • Describe the evidence for off-label uses for clozapine in children and adolescents
  • List challenges to clozapine use in young patients
  • Discuss he potential contributions that peer supports can bring to patients and families
Launch Video
Talking to Patients and Families about Clozapine/Motivational Technques

Gopal Vyas, DO and Fred Nucifora, DO, MHS, PhD


  • Describe strategies to introduce clozapine as a treatment option to patients and families
  • List elements of clozapine treatment that are important to include in the patient and family discussions
  • Delete barriers to care to help patients and families have an optimal clozapine experience
Launch Video
Clozapine Respones - Dont Miss it, What to do if Patient gets "Worse on Clozapine" Adequacy of Clozapine trial and Discontiuation of Clozapine When Needed

Gopal Vyas, DO

  • Describe the components of an adequate clozapine trial
  • List potential reasons why a patient may "worsen" on clozapine
  • Determine ways to measure clozapine response
  • Outline a plan for clozapine discontinuation
Launch Video
Clozapine and Augmentation Options

Fred Nucifora, Ph.D., D.O., M.H.S

  • List the indications for an augmentation strategy in a clozapine-treated patient
  • Describe nonpharmacological augmentation strategies for clozapine-treated patient
  • Discuss evidence-based pharmacological augmentation strategies for clozapine-treated patients






Launch Video
Using Clozapine in Patients with Medical Comorbidities

Megan Ehret, PharmD, MS, BCPP

  • Review clozapine use in those with medical comorbidities
  • Discuss clozapine rechallenge in those with medical comorbidities
  • Describe the risk-to-benefit ratio calculation in patients with medical comorbidities
Launch Video
Management and Coodination of Care During Hospitalization Transition and Conclusion of Series

Marie Mackowick, Pharm.D., BCPP and Deanna L. Kelly, PharmD, BCPP

  • Outline the challenges associated with clozapine use in transition of care
  • Describe methods to ensure clozapine continuation during transitions
  • Discuss the next steps for clozapine use after the conclusion of the CHAMPION ECHO series
Launch Video Attestation

© 2017-2022 University of Maryland School of Medicine